ZIF‐8 Based Active Wound Dressing for pH Modulation and pH‐Responsive Delivery of Curcumin and Zn²⁺: Effect of Acidity on the Drug Release for Antibacterial and Antioxidant Efficacy

A wound evolves with variable pHs depending on the healing stage, and maintenance of mild acidic condition can help by deterring formation a biofilm. Herein, dual-layer dressing an acid-responsive zeolitic imidazolate framework–8 (ZIF-8) layer acid-modulating is designed to control acid-dependent release therapeutic agents for improved process. The outer coated curcumin-incorporated ZIF-8, where curcumin zinc ions are released upon dissociation ZIF-8 in condition. inner layer, pH modulator, fabricated electrospinning polyvinylpyrrolidone addition acetic acid. In vitro test shows that attains considerably higher Zn2+ under Combined dual exhibits facilitated effective regardless environmental pHs, attributed proper modulation about 6.5. anti-oxidant activity antibacterial confirmed. study highlights novel proof-of-concept design active demonstrating functions regulation stimulus-responsive drug delivery.